TSH and mitochondria

[David Staup]

Part of my Statin damage misdiagnosis was hyperthyroid as described here:

http://www.medicalnewstoday.com/releases/139691.php

They "nuked" my thyroid which makes me not just hypo but no thyroid function and dependent on replacement hormones for life.
From the beginning when they tried to adjust my dose to bring my TSH down to the normal range..my condition worsened and I would have to demand a return to the lower dose..
Because of new healthcare regulations I just had to go through testing and my doctor "had to suggest" that I up my dose. Rather than go through that again I decided to try and find out why a high (according to them) TSH worked best for me. I found the following which anyone on thyroid replacement should look in to:

http://www.fasebj.org/content/24/5/1525.full

"Thyrotropin powers human mitochondria"

excerpts:

"Here we demonstrate that the neuropeptide hormone thyrotropin (TSH), which controls thyroid hormone production, exerts a major nonclassical function in mitochondrial biology. Based on transcriptional, ultrastructural, immunohistochemical, and biochemical evidence, TSH up-regulates mitochondrial biogenesis and consequently activity"

and

"TSH up-regulates MTCO1 mRNA (quantitative RT-PCR) and significantly enhances complex I and IV (cytochrome-c-oxidase) activity."



And this study:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682478/

"Extreme Longevity Is Associated with Increased Serum Thyrotropin"


Doc says this covers me and him ...no more forced tests for me!

David