by sos_group_owner » Wed Jan 17, 2007 1:14 am
Hi "catamaran"
Re: His homocystiene is slightly elevated at 11.
Although most labs say that <11 (and even as high as 15 micromoles per liter of blood) is a healthy level for homocysteine (Hcy), there is no safe "normal range" for (toxic) Hcy. Optimal Hcy levels should be 6.2 or less. For each 3-unit increase above 6.3, there is a 35% increased risk for myocardial-infarction (heart-attack). (American Journal of Epidemiology, 1996, 143[9]:845-59)
Epidemiological data reveal that Hcy levels above 6.3 cause a steep, progressive risk of heart attack.
(American Heart Association's journal Circulation, Nov. 15, 1995, 2825-30)
In addition to folic acid, B6 and B12, some might also need TMG (trimethylglycine), P-5-P (pyridoxyl-5-phosphate), zinc, inositol and/or choline to control Hcy.
Excerpt from an excellent article that explains homocysteine:
"There are three biochemical pathways used by the body to reduce homocysteine. In one pathway TMG donates a methyl group which detoxifies homocysteine. In this reaction, TMG is reduced to DMG (dimethylglycine), that familiar-product sold as a supplement for its energizing effects. In the other routes, folic acid, B12 and B6 convert homocysteine into nontoxic substances. Some people can't utilize one or another of these pathways. That is why a combination of all these nutrients is most effective for lowering homocysteine. In some people vitamin B may not be efficiently converted to its active co-enzyme form, pyridoxyl-5-phosphate. In that case supplementing with pyridoxyl-5-phosphate would be necessary. "
Source: "CHOLESTEROL IS NOT THE BAD GUY!!!" By Dr. Deb Baker
[http://www.y2khealthanddetox.com/truthchol.html]
An additional note for those taking therapeutic doses of niacin...
"A controlled study found that 1,000 mg or more per day of niacin raised homocysteine levels."
(Garg R, Malinow M, Pettinger M, et al. Niacin treatment increases plasma homocyst(e)ine levels.
Am Heart J 1999;138:1082–7)
Also LDL is not the issue... it's when LDL becomes 'oxidized'.
Things that create "free radicals" and oxidized LDL... Smoking, high blood sugar levels (diabetes), stress... Risk factors that damage the "endothelium" include elevated levels of homocysteine, blood sugar, insulin, cortisol (stress hormones), triglycerides, smoking and deficiency in some vitamins, such as C and the B's.
When you get a chance, read the complete article titled, "Is Heart Disease All Due to Blood Clots?"
[http://www.thincs.org/Malcolm.htm#clots]
Fran