Excellent site for Cholesterol info + SLCO1B1 marker

[cjbrooksjc]

This is one of the most inclusive sites I've run into on the subject of Cholesterol.

**http://eatingacademy.com/

"ClicK" on the title above the photo to read parts 1 to 6 ( I to VI) This is very spartan language - no punches pulled stuff.



One other thing. Someone was wondering why Drs can't determine beforehand if a patient is prone to Statin AEs; they absolutely CAN: Google SLCO1B1 (slco1b1), or go here: **http://www.bostonheartdiagnostics.com/science_portfolio_statin.php

Best,

Brooks

[lars999]

Thanks Brooks!!

You just provided some nice additional focus to my "genes" self-study.

FYI, there is also COQ2, "Ubiquinol regulator" gene. I have no idea at moment how these two genes interact, or, if they are totally separate genes.

Lars

[lars999]

Here is Internet address for full article in New England Journal of Medicine
http://www.nejm.org/doi/full/10.1056/NEJMoa0801936#t=article

Here is another full article.
http://content.onlinejacc.org/cgi/reprint/54/17/1609.pdf

I will post additional Internet addresses as I find them.

Hope these addresses work for you. Typically, I have to "poke around" a bit till I find a full article I can download. I search for full articles because long ago I found PubMed abstracts to be little more than advertisments.

NOTE: This/these gene-studies were done on individuals selected from drug testing done to get a statin drug approved. Therefore, likely that ALL individuals had passed a routine "run in test" and showed very little or no adverse effects from statin.

NOTE: Only muscle myopathy is being considered as adverse side effect.

Lars

[lars999]

NOTE: Now that I am well into reading and digesting the two full articles noted above, it is strikingly obvious that the British group (NEJM artical) has a very narrow view of adverse side effects, based on only clinical studies. Authors of American group (American College of
Cardiology Foundation) note the large difference in % adverse side effects in clinical trials (very low) vs actual practice (25% to 50% noncompliance).

Read both articles with care!
Lars

[lars999]

For those data hogs amongst us, here is another full article re effects of SLCO1B1 variants.

http://circgenetics.ahajournals.org/content/3/3/276.full.pdf

Lars

[lars999]

And here is another full article, this one about Vitamin D and SLCO1B1

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081682/

Thank you Brooks for opening up such a fruitful line of Internet searches!!
Lars

[lars999]

And here is a Canadian report, also full article.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1832194/

Lars

[eml256]

The most comprehensive reference I have found on slco1b1 is an academic dissertation :
PHARMACOGENETICS OF SLCO1B1: POPULATION GENETICS AND EFFECT ON STATINS
Marja Pasanen

*https://www.doria.fi/bitstream/handle/10024/42771/pharmaco.pdf

[eml256]

In reference to the post about the COQ2 gene: it is completely separate gene from slco1b1
as per 23andme:
The authors found an association between myopathy and a SNP in the COQ2 gene, which is involved in cellular energy production. Patients who had a C at both copies of rs4693596 had more than twice the odds of myopathy as those with the CT or TT genotype.

Who Genotype What It Means
CC Moderately higher odds of myopathy while on statin therapy.
CT Typical odds of myopathy while on statin therapy.
TT Typical odds of myopathy while on statin therapy.
Citations
Oh J et al. (2007) . “Genetic determinants of statin intolerance.” Lipids Health Dis 6:7.

[lars999]

Thank you eml256!!

I have been seeing articles by M. Pasanen and watching for full-text pubs from Univ. Helsinki -- now I can read all of hers.

Thanks also for info that COQ2 is separate from SLCO1B1 -- for a newbe to stuff about genes, that kind of information helps us find our way through the "gene jungle".

Lars

[cjbrooksjc]

Lars & eml256:

Thank you for all the research. I have a week full of activity ahead but will get back to this subj when time permits - LOTS of valuable information.

Best,

Brooks

[lars999]

Here is another website of company offering gene analysis for specific medical and other investigations. Link takes you to their section of Statin Response.

*https://www.23andme.com/health/Statin-Response/

This commercial lab is certified by Clinical Laboratory Improvement Amendments (CLIA)
http://www.cms.gov/Regulations-and-Guidance/Legislation/CLIA/index.html?redirect=/CLIA/

Regards,
Lars

[lars999]

Here is Wikipedia article about 23andMe

http://en.wikipedia.org/wiki/23andMe

Lars

[David Staup]

http://www.ncbi.nlm.nih.gov/pubmed/21297370

genes in addition to SLCO1B1 that make one suseptable to statin damage

and as I stated here:

"I suspect that I have a glycogen storage disease that made me more suseptable to statin damage so I'm guessing that there are more preconditions that make someone prone to statin damage than the new assay will identify. "

http://www.spacedoc.com/board/viewtopic.php?t=1965


A glycogen storage disease means you are more likely to be damaged by statins.

David

[lars999]

Yesterday I received my genetic information from 23andMe. Of course, one of first things I looked at was their estimate of how suseptable I am to statin damage -- "average" is answer they give, ie., the very low probability touted by statin drug companies for this "safe" drug. Maybe this would have been good answer for my early months, maybe my first year on Lipitor, BUT it is NOT consistent with what happened to me during all those years when my total cholesterol was about 150 to 140. In addition, they only considered statin-induced muscle pain in their analysis, which was NOT what affected me so badly.

This is just my first observation. In coming weeks/months I will be digging quite deep into my genetic data, into the medical-genetic studies 23andMe uses in their estimations, comparing them with various blood chemistry analyses (for such genetically controlled markers as lipoprotein (a), etc.).

Most likely, I will post my findings in one or more new threads.

On first hours of browsing through genetic data provided by 23andMe (for a whopping $299 US dollars!!) I am quite satisfied with what I received. Broadly, it is consistent with what I already knew. I can already see that I will be critical of what they are doing re predicting adverse responses to statins. At first blush, I expect that their estimates of susceptability to statin damage are way too low because they are based on short term studies that rejected lots of participants based on their adverse reactions to a statin drug.

I would encourage others that have suffered serious statin damage to invest $299 and the large amount of time needed to truly digest this huge pile of data.

Regards,
Lars