After I saw the effects of Benadryl I looked at the food choices I had gravitated to and found that most of the vegetables, herbs, and some of the spices are natural antihistamines.....
Some time back I came across the following about the effects of estradiol (a form of estrogen) on mitochondria:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593138/
"Estrogenic Control of Mitochondrial Function and Biogenesis"
Prompted by some posts on another health forum (autism) that has connections to mitochondrial dysfunctions, I started looking and found that virtually all of the veggies and herbs I use are either anti-histamine or pro-estrogen or both.
Testosterone also plays a role here but it's beginning to look, to me, that estrogen is the bigger player, even in men.