polyradiculopathy

[badodge]

Rather then write out my horror story about the effects Stains have on my body-as I see by just a few reads-you all seem already well aware of the nerve damage. Both my sister and I got off Statins after we began experiencing very strange symptoms.

My sister (a Lipator user) has now been diagnosesed with polyradiculopathy. Anyone heard of it? I tend to question her doctor as that is the diagnoses for her legs and feet nerve damage and "carpal tunnel"the explaination for her arm and hand damage.

[catspajamas]

Do you mean periferal neurapathy?.....never heard of the poly ..thing....I have pn from zocor....feet. very painful...hands tingle...after being off zocor for 5 years....Not a easy thing to accept that a med ruined your life.

[badodge]

No, I actually did mean polyradiculopathy. I am well aware of the past and present reseach on peripheral neuropathy- but this polyradiculopathy was new to me.

I agree it is sad that a medicine which had so much promise has left so many very sick and for what there appears to be no cure for. It is even more sad that so many knew that adding coenzime 10 might have helped stop the damage to the nerves. It is interesting that now all people taking the Statins are informed in their information sheet to take CoQ10 and the new Statins coming out next year will have CoQ10 in them. But for the rest of us the damage has been done.

[Dee]

I googled it and found this link, which may be helpful:

*http://www.raysahelian.com/neuromuscular.html

[adec]

Hi badodge and welcome to the forum. I hope you continue to read, post, and share further details of your individual stories with us. I believe it can be of great assistance to others here.

I've been doing a lot of reading lately about the demyelization of nerves.... in regards to statin-induced damage. This perhaps starts with a chronic inflammation response. Inflammation can slowly wear away the protective cells surrounding nerves in your central and peripheral nervous system. This myelin coating is much like that of a power cord, which keeps electrical impulses properly connected and contained with minimal resistance. These glial cells can wrap around the nerve axons as many as 100 times.

Eventually, unraveling this sheathing causes a slowing or blocking of nerves that control strength, tactile sensation, vision and hearing, localization and coordination etc. In its wake tiny little glial scars or lesions remain, making regeneration of these nerves very difficult. Most doctors understandably do not see much potential in complete nerve regeneration, or in the remyelization of nerves. However these concepts are slowly starting to gain greater acceptance. I've tried to make this explanation as easily understood as possible.

The worst cases of these demyelinating diseases would be considered multiple sclerosis, or in your sister's case possible polyradiculopathy. Doctors often seem to misdiagnose or misattribute the root cause of statin damage to other primary diseases with huge names.They simply aren't aware of the causative relationship between statins and these side-effects. To be frank, most doctors I've spoken with know little about how cholesterol works, or its primary importance in the human body. They are the ones quickest to prescribe statins as a cure-all to their patients.

I believe reversing this demyelinating process is the missing final step in healing statin-induced pathologies. By reducing these glial scars and/or increasing new glial cell formation, perhaps the body would have the materials needed to heal itself. This relates to anyone here suffering from statin-related neurological cytotoxicity.

First you must contain any remaining inflammation response with a Cox inhibitor. Next, by increasing cAMP, these glial scars are slowly dissolved. Cyclic AMP or cAMP is the messenger protein receptor that directs cells to grow. Next you must increase nerve growth factors surrounding these nerves. If you're interested, or anyone else, I can provide names of common supplements that have been proven to greatly assist.

[poohhel]

[quote="badodge"] My sister (a Lipator user) has now been diagnosesed with polyradiculopathy. Anyone heard of it? I tend to question her doctor as that is the diagnoses for her legs and feet nerve damage and "carpal tunnel"the explaination for her arm and hand damage.[/quote]

badodge: polyradiculopathy is nerve damage/inflammation of several nerves in the spinal column/system... I was diagnosed with this as well and an EMG test and NCV test showed evidence of pinched nerves in the lower back and neck. But after xrays, MRIs, and CT Scans .. there was no evidence as to where the pinched nerves were occurring... no evidence of anything wrong with my spinal column or disc, etc.

I finally went to a foot and hand specialist and was diagnosed with carpal tunnel in my wrists/hands and tarsal tunnel in my ankles/feet. I have been doing Physical therapy for my hands and the numbness is fading and rest helps relieve the pains. For my feet, I just recently had tarsal tunnel release on my left foot... it's only been 1 week but I do not have the numbness or burning sensations in my feet and my I do not have the shooting pains/cramping in my calf or ankle... so it appears it has worked.

[imanut]

Personally, I was diagnosed as having CIDP---chronic inflammatory demylenating polyradicularneurapathy. Supposedly a cousin to Guillan Barre disease, distant relative to others. i.e. MS.

Me----I still think it was caused by Zocor.

[adec]

I would strongly suggest trying these ten supplements for demyelinating diseases:

=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+
1. INOSINE has been shown to act as a strong neuroprotective, which can decrease inflammation and increase axonal growth.

2. FORSKOLIN has been shown to increase cyclic AMP or CAMP concentrations, and in turn this activates the proliferation of glial cells vital for proper nerve transmission. cAMP plays a very vital role in intracellular signaling.

3. ROYAL JELLY has been shown to increase GDNF or levels of glial cell line-derived neutropic factor in the hippocampus and cerebral cortex. This would act as a neuroprotective agent in neuronal axons.

4. ACETYL L-CARNITINE has been shown to increase NGF or nerve growth factor. This increases the critical proliferation of nerve cells and their survival.

5. COENZYME Q10... this one goes without saying. :)

6. MAGNESIUM has been proven to increase the structural integrity of nerve transmission.

7. RIBOSE has been proven to increase such important nucleotides such as AMP, ATP, and ADP. This can increase mitochondrial activity, and levels of cAMP or cyclic AMP.

8. MSM has been shown to increase permeability of cells, allowing these factors to penetrate deeper into the central and peripheral nervous system.

9. MANNITOL or MANOOSE has been shown to increase IGF-II or insulin-like growth factor, which plays an important role in nerve physiology and communication. MANNOSE is the foundation of all essential sugars.

???. GLUCOSAMINE and CHONDROITIN could theoretically help to decrease and inhibit glial scaring, thus increasing neuronal repair and growth.
=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+=+



Many of these ingredients can be had fairly cheaply in bulk powder form at beyond-a-century.com and bulknutrition.com. In supplement form, these can be had cheaply at Vitacost.com and their NSI house-brand. I just request that everyone trying these supplements report back on their progress, in order to potentially help others with the same condition.