Thesis

[damaged]

I'm interested in any opinions on this thesis.

http://edoc.unibas.ch/1317/1/Peter_Mullen_Thesis.pdf

Thanks,
Mike

[David Staup]

Mike,

It looks to me that they have answered many of the questions. It would explain everything for those that recover on suspension of the statin. I believe I see the final answer in the paper but their objective did not include answering the question that is most important to you and me. That is, what is the mechanism that causes permanent damage in a significant portion of the affected population?

I believe that the ubiquinol reductions that were noted and that did not cause a reduction in ETC function may be always true and maybe not always, but that only leads me to believe that the noted reduction in ubiquinol is not affecting the ETC by reserving most of the ubiquinol for the ETC at the expence of ubiquinol in it's other role, that, as the primary antioxident in the mitochondria! Thereby allowing a rate of mtDNA mutations that overwhelm the repair mechanisms.

Excellant find Mike! Thanks for posting it.


David

[damaged]

Thanks David.

I was prompted to start poking around again after reading this addition to the Mayo page:
"Other treatment options include supplements to reduce the myotoxicity symptoms attributable to impairment of fatty acid oxidation or mitochondrial dysfunction that result from the statin therapy.
Patients who are either on statin therapy or have a family history of severe reactions to these agents but have never actually taken a statin drug can be referred to the Statin Intolerance Clinic."

http://www.mayoclinic.org/medicalprofs/ ... linic.html

I have a feeling that the research is still going on, but that the recomendations for supplements is nothing more than a shot in the dark.

I just wish it was stated as such.

I'm tempted to find a doctor that's willing to speak to Mayo, and ask directly if they're seeing any real results.

A year ago, I called and I was told that they were still simply collecting data.

..

This seems more realistic -

"With regard to CoQ supplementation in order to
mitigate statin myopathy, two recent trials were under-
powered and a large controlled trial is required. The
identification of individual genetic risk factors for myotoxi-
city is a key challenge for future pharmacogenomic
research."

http://faculty.ksu.edu.sa/23491/Myopath ... opathy.pdf

....



David Staup -
"what is the mechanism that causes permanent damage in a significant portion of the affected population?"


I believe this speaks to your question....

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092639/

..

I have a hard time keeping up with the exact conditions/progress of members of this board.
I'd like to hear from someone that was crippled to the extent that I am, and actually experienced improvement.
I can't walk more than 100 yards without profound pain for two days afterwards. My muscles are wasting away, and if anything, the pain is beginning to be present even while at rest.
I continue to see posts from those that state that they are trying something new - that "seems to be working".
But, I've given up buying every supplement mentioned.
So it's maddening to read of "supplements to reduce the myotoxicity symptoms attributable to impairment of fatty acid oxidation or mitochondrial dysfunction" stated so matter-of-factly by the folks at Mayo.

Later,
mike

[David Staup]

In the following quote from the article:

"Myopathies induced by drugs most commonly result in necrosis, vacuolar changes, or mitochondrial dysfunction"

only there do I see anything that even points to anything long term

byt maybe I'm slow today



Mike, I have been addressing this as Mito and have improved my stamina and reduced the other effects only by following the "best known practices" common to that group.

the best source in one place that I've found is here:

"http://drmyhill.co.uk/wiki/CFS_-_CFS_Book_published_by_Dr_Sarah_Myhill

David

[damaged]

David:
"only there do I see anything that even points to anything long term
byt maybe I'm slow today"
..

No...you're not slow.
I recieved a list of PDFs in an email, and linked to the wrong one.
sorry.
The reference to mechanisms was found in the first link that I posted.
Nothing new, really:

Mechanisms
The ultimate cause of statin myopathy is unknown, but
possible mechanisms include decreased sarcolemmal
cholesterol, mitochondrial dysfunction from reduction
of coenzyme Q (CoQ), and depletion of key isoprenoids
that control myofiber apoptosis. The observation that
characteristic structural abnormalities of statin myopathy
can be reproduced by extraction of cholesterol from
skeletal muscle fibers in vitro supports the hypothesis
that cholesterol lowering per se contributes to myocyte
damage and suggests further that it is the specific lipid/
protein organization of the skeletal muscle cell itself that
renders it particularly vulnerable [7].
The competing mitochondrial theory is based on the fact
that statins inhibit the synthesis of mevalonate, a pre-
cursor of both cholesterol and CoQ. Statins have been
known to reduce circulating CoQ levels in humans since
1990 [8], and this finding <snip>

I'll look over the PDF that I D/Led from your link.
Thank you,
mike