by crandreww » Thu Jun 05, 2008 2:24 pm
Hello folks, my name is Chris Wunsch, and until Sept 2002, I was on Lipitor 10mg for the previous 3.5 years for familial high cholesterol which I knew I had when I was 20, in Nursing school and had a physical exam.
I just ate better (so I thought) for 9 years, when my father was treated for a heart attack, and had 7 vessel Bypass surgery. He was diabetic, overweight, high cholesterol and had high blood pressure.
At my next physical exam, my doctor wanted me to begin statin therapy, which after some research, I agreed to take it, as I gave it to nearly every patient I cared for in the Critical Care unit I worked in, and there were very few reported side effects. I tolerated this poison well until July 2002, when I was beginning to have bouts of terrible headaches, accompanied by occasional episodes of confusion.
I was seen in the Emergency room on one occasion, where I was diagnosed as having a "Migraine Variant" even though I had rarely ever had headaches in the past. I was sent home with a prescription for Imitrex (a Migraine Medicine) which came in injectable form, as I was a Registered Nurse, and would be able to give myself the inhection when I needed it, so I was instructed on how to give this medicine to myself, and I was discharged home.
Over the next several weeks, my headaches were beginning to worsen, with more frequent bouts of confusion and disorientation, a new symptom of Ataxia and increasing lethargy. When on one afternoon, my wife took me to the ER again, where I was evaluated and diagnosed with a Migraine variant again, and was sent home again.
My wife tells me I pleaded with the ER doctors to perform an MRI scan, to which they declined. And the attending doctor had agreed to get a CT scan, which I did not want, but agreed to just to take a look at what was going on inside my head. So I had the CT scan and the results showed no abnormality, and I was sent home again.
After I got home I was so angry and disgusted at the ER for not getting an MRI scan like I wanted, I called my Primary care MD at home, and told him what was going on, and that I feel I need to have an MRI scan, to which he agreed to, and it was scheduled for the following day, as It was Sunday. I went to the clinic the following day for my MRI scan, and the results were multiple scattered lesions throughout the white matter. And now I was referred to a neurologist who performed a neurological exam along with some more tests, and he told me he thought I had "atypical multiple sclerosis".
As a registered nurse, I knew that this was not going to be a fun thing to have, but I knew it was survivable for the most part, and that some people who have this disease, do rather well. But I did not feel confident with this diagnosis, and I sought a second opinion at the University Hospital, with an MS specialist, at my appointment, he reviewed all of my films, lab tests etc, and examined me and performed a Lumbar puncture, to analyze my spinal fluid.
At this appointment, this Dr. informed me that he did not believe what I had was MS at all, he could not give me a diagnosis, but felt pretty strongly that I did not have MS, so I was sent home with a recheck appontment in 2 weeks.
Over the next week or so, I continued with the unbelievable headaches, dizzyness, confusion, ataxia, but this was now being accompanied by slurred speech and visual changes, my wife tells me I was seeing flashing lights.
I was seen by an opthomalogist, who offered no insight into my condition, and I was seen by my home town neurologist, who thought the lesions on my brain may be small strokes, so I was sent to the cardiology clinic, where I had a transesophageal echocardiogram to assess for clots in my heart, this test was negative, and I was back to not knowing what was going on with me.
My wife had called my Neuroligist at the Univ hospital, who told her that I should be evaluated immediately, and we dropped our 2 year old son off at my parents house, and we headed to Madison to be evaluated, where I was given a mini mental exam, which I failed miserably, and I was admitted. and remained for the next 28 days. I had multiple tests, I was seen by every Neurologist at the Hospital, and I underwent a brain and muscle biopsies.
My Brain biopsy revealed focal areas of vacuolization of both neurophil and neuronal cytoplasm. Some of the vacuolization is perivascular. Electron micrographs show abnormal mitochondria with thickened disarrayed cristae and inclusions of lysosomal and autophagic vacuoles. (Hence the headaches, as my brain cells were being assassinated one by one, due to the deprivation of Ubiquinone from the brain cells.)
The impression of the brain biopsy was " the changes seen by light and electron microscopy are most consistent with a "mitochondrial encephalomyopathy" such as MELAS syndrome.
When I was in the hospital, I was evalated by a visiting neurologist from Harvard, who evaluated my biopsies, lebs and other clinical data, and he suggested starting me on a mitochondrial cocktail which included Vit C, 500mg 2x/d, Multi Vit QD, Vit E 400iu 1x/d, Vit B6 25mg 1x/d, L Carnitine 1000mg 2x/D, CoQ10 150mg 2x/D,.
It wasn't until I had been on this cocktail for about 4 days, that I began to improve, I was beginning to speak coherently, was able to walk unassisted, and I was alert and oriented to person, place and time, which I hadn't been for the previous 20 days. I knew my wife and son, and my parents and siblings which I hadn't known throughout my hospitalization.
I was to be transferred to a nursing home pending bed placement, until I began to improve like this, and after a few days of improving this way, I was discharged home with aggressive physical, occupational and speech therapies. I was 34 years old at the time of this hospitalization, and I couldn't work at all anymore due to continued extreme exhaustion, fatigue, bilateral leg pain, tinnitus in my R ear, myoclonus in both ankles and in both hips.
It was about 3 months after I was discharged, that I thought I could go back to work as I could walk and talk, so I called the company I worked at, and they agreed to take me back, so I went back part time, 3 days per week a few hours per day, and after about 4 weeks of trying to do my job, I was approached by my boss, who informed me that while she appreciated my wanting to work, my work product was inconsistent with employment, as it took me 4-5 days, to complete the work that used to take me about an hour, and that this was not going to work. She recommended I go back on disability, which I reluctantly agreed to.
At my next appointment to follow up with my neurologist, I also had an extensive neuropsychiatric exam, which reveled, moderate cognitive impairments in the context of intact verbal abilities, the neuropsychological impairment are considered sufficient severity wo significantly affect his occupational skills and efficiency. His data are consistent with a cognitive disorder attributable to his recent neurological illness. Some of the patients cognitive and behavioral changes appear consistent with a frontal lobe pathology.
I remained off of work for several more months, when I saw Dr. Beatrice Golomb MD, PhD of the UCSD Statin Effects study, and she was discussing her study she was to be doing, so I immediately enrolled. After having all of my medical information to the UCSD, and I enrolled. After approximately 1 year, I received a call from Dr. Golomb who informed me that I was one of several in her study who were diagnosed with a mitochondrial myopathy and that it was her expert opinion, that my Lipitor use was the likely causal contributor. I asked her about the holes in my brain as evidenced on the biopsy, and she told me that, Ubiquinone (CoQ10) is responsible for the control of apoptosis.
I cant begin to tell you how much I have researched this subject, mainly because my neurologist refuses to accept the notion that what I had was anything but a virus. I know I need to fire him, useless tool that he is.
It is now approaching 6 years since the onset of my illness, I have a satisfactory answer, in that it was the result of Lipitor which caused my disability, and every lawyer I have discussed this with, agreed I have a case, but no one is able or willing to take a case of this magnitude. And now, the statute of limitations is past, soI just have to be happy to try to educate the world not to take these poisons, and to every patient I have ever given a statin drug to, I am sorry, and I ask your forgiveness.
God Bless!
Christopher Wunsch