by sos_group_owner » Fri Nov 18, 2005 4:29 pm
Hi Samiam,
I've never heard arthritis of the muscle. Arthritis is a joint and connective tissue disease. A CPK is a blood test that measures creatine phosphokinase (CPK), an enzyme found predominantly in the heart, brain, and skeletal muscle. When the total CPK level is substantially elevated, it usually indicates injury or stress to one or more of these areas.
Source: nlm.nih.gov/medlineplus/ency/article/003503.htm
Elevated Creatine Kinase (CK) or Creatine Phosphokinase (CPK) Levels may indicate Statin-Induced Myopathy.
A muscle biopsy might also be required to confirm muscle damage.
Some can sustain muscle damage almost immediately from statin drugs.
I've pasted Vytorin info below. Maybe something in the literature will shed some light on your Mom's situation.
You definitely need to keep pressure on her doctors to get to the bottom of her situation and to get her the proper treatment.
Fran
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Vytorin
ezetimibe and simvastatin (eh ZEH teh mib and SIM va stah tin)
Source: drugs.com/vytorin.html
What is the most important information I should know about Vytorin?
• Do not stop taking Vytorin unless directed to do so by your doctor. It may be weeks or months before beneficial effects are seen from this medication.
• Rare cases of muscle problems and liver problems have been associated with the use of Vytorin and other similar medicines. Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, especially if accompanied by a fever or flulike symptoms or yellowing of the skin or eyes, abdominal pain, unexplained fatigue, dark colored urine or pale colored stools. These may be early symptoms of muscle or liver problems.
• Do not take Vytorin without first talking to your doctor if you have liver disease.
• Alcohol and Vytorin can both be damaging to the liver. Alcohol should be used only in moderation. Discuss the use of alcohol with your doctor so that the potential for liver problems can be determined.
• Do not take Vytorin if you are pregnant, could become pregnant during treatment, or if you are breast-feeding a baby.
What should I avoid while taking Vytorin?
• Eat a low-fat, low-cholesterol diet. To see beneficial effects from Vytorin avoid fatty, high-cholesterol foods.
• Grapefruit and grapefruit juice may interact with Vytorin. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.
• Both alcohol and ezetimibe/simvastatin can be damaging to the liver. Alcohol should be used only in moderation. Discuss the use of alcohol with your doctor so that the potential for liver problems can be determined.
• Avoid prolonged exposure to sunlight or artificial UV light (e.g., tanning beds). Vytorin may increase the sensitivity of the skin to sunlight, and burning may result. Wear protective clothing and sunscreen if exposure to the sun is unavoidable.
What are the possible side effects of Vytorin?
• Rare cases of muscle problems and liver problems have been associated with the use of Vytorin and other similar medicines. Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, especially if accompanied by a fever or flulike symptoms or yellowing of the skin or eyes, abdominal pain, unexplained fatigue, dark colored urine or pale colored stools. These may be early symptoms of muscle or liver problems.
• If you experience any of the following serious side effects, stop taking Vytorin and seek emergency medical attention or contact your doctor immediately:
· an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
· decreased urine or rust-colored urine; or
· blurred vision.
• Other, less serious side effects may be more likely to occur. Continue to take Vytorin and talk to your doctor if you experience
· gas, bloating, nausea, stomach upset, heartburn, abdominal pain, constipation, or diarrhea;
· cough;
· tiredness;
· headache; or
· insomnia.
• Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
What other drugs will affect Vytorin?
• Do not take Vytorin without first talking to your doctor if you are taking any of the following medicines:
· cyclosporine (Sandimmune, Neoral);
· atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Altocor, Mevacor), pravastatin (Pravachol), rosuvastatin (Crestor) or simvastatin (Zocor);
· gemfibrozil (Lopid), fenofibrate (Tricor) or clofibrate (Atromid-S);
· niacin (Nicolar, Nicobid, Slo-Niacin, others);
· erythromycin (E-Mycin, E.E.S., Ery-Tab, others), telithromycin (Ketek) or clarithromycin (Biaxin);
· cholestyramine (Questran) or colestipol (Colestid);
· an antifungal medication such as itraconazole (Sporanox), fluconazole (Diflucan), or ketoconazole (Nizoral);
· nefazodone (Serzone);
· digoxin (Lanoxin, Lanoxicaps);
· warfarin (Coumadin);
· a protease inhibitor such as amprenavir (Agenerase), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), lopinavir-ritonavir (Kaletra), or saquinavir (Invirase, Fortovase);
· amiodarone (Cordarone, Pacer one); or
· verapamil (Calan, Covera-HS, Isoptin, Verelan).
• You may not be able to take Vytorin, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
• Drugs other than those listed here may also interact with Vytorin. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.