by cjbrooksjc » Mon Jul 07, 2008 12:18 pm
Jl: Actually, I was wondering if Policosanol employed red yeast rice. Lowering LDL is not necessarily a bad thing since it is small, dense LDL that embeds in the inflamed artery wall causing blockages:
" The most pronounced lipoprotein abnormalities in patients with early-onset coronary heart disease are high plasma triacylglycerol and low HDL cholesterol, with lesser elevations of LDL cholesterol. But the LDL particles in these individuals are somewhat smaller and more dense than in those with a more favorable lipoprotein profile. The relative contribution of the individual lipoprotein abnormalities that constitute the ALP to the increased risk of atherosclerotic vascular disease is unclear; however, plausible arguments for the atherogenicity of small, dense LDL particles, particularly an increased susceptibility to oxidative modification as compared with larger, more buoyant LDL particles, have heightened interest in this component of the ALP.
Predominance of small, dense LDL particles, which is commonly determined by gradient gel electrophoresis of apolipoprotein B–containing lipoproteins, is called LDL-subclass pattern B, whereas predominance of larger LDL particles is called pattern A. Small, dense LDL particles can be produced by the action of hepatic lipase on larger LDL species that are triacylglycerol enriched "
**http://www.ajcn.org/cgi/content/full/71/6/1390
It would seem then that a focus on decreasing tirglycerides in the blood would reduce the amount of small, dense LDL and help lessen the number of, or the seriousness of, artery wall lesions.
I knew about the benefits of vit C, and as for the increase of cholesterol, it is a natural event as we grow older and may be simply, in many cases, the body's way of protecting itself. I've tried to google PCos to see if there is any complete operating explanation available, but have found nothing concrete as yet.
Best,
Brooks