by cjbrooksjc » Sat Apr 21, 2007 6:51 pm
Lars... I won't try that again (universal translator) My Goodbye was supposed to be Good Day, or Guten Tag, (I thought that looked funny) and yes, 'consider' would be the correct translation. Let's stick to English from now on. I can butcher that on my own without help.
CoEnzymeQ10 (CoQ10) is manufactured by the liver in something called the mevalonate pathway and is essential to proper cell function and so is ESSENTIAL to life. Cholesterol is also produced by the same pathway. Satins block or 'squeeze' this pathway to prevent cholesterol production. Unfortunately, this also blocks CoQ10 production. CoQ10 is responsible for producing L-Carnitine, an amino acid, that makes ition possible for the mitochondria of each cell to absorb and use long chain fatty acids as fuel. Net: No CoQ10 = reduced/eliminated L-carnitine production = cell starvation,disfunction, or cell death =you get very sick and tired.
That's MY answer
I've added a more complex answer about Statin toxicity below. It was written by the Forum Author, Dr. Graveline. It's more complete, but technical and the language is potentially more difficult.
To someone who understands the mevalonate pathway, all the side
effects we talk about seems so inevitable. Why in the world did we allow the drug companies to do this to us, twenty years ago, when they first conceived statin reductase inhibition, thereby "girding the entire mevalonate metabolic tree? Inevitably, first comes cholesterol inhibition, the original justification for statins, the excess of which (statins) cause our terrible cognitive problems; then comes CoQ10 with a huge list of side effects relating to energy, cell wall integrity and anti-oxidation; then dolichols with side effects of altered neuropeptide formation, diminished immunoresponsiveness and glycolysis inhibition that only now are we just beginning to really understand; then provocation of excess tau protein production because of inhibition of normal Glycerl-glyceryl pyrophosphate pathway and finally comes seleno protein inhibition resulting in both myopathy and cognitive side effects. Even twenty years ago our biochemists knew this would happen with reductase inhibition. Why did we allow it to occur? Spacedoc
Please forgive my poor attempt at your beautiful language.
Regards,
Brooks